Mechanism of bactericidal action of aminoglycosides.
نویسنده
چکیده
[This corrects the article on p. 341 in vol. 51.].
منابع مشابه
Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides.
Among the pleiotropic effects of aminoglycosides, their irreversible uptake and their blockade of initiating ribosomes have appeared to explain their bactericidal action, while the contributions of translational misreading and membrane damage and the mechanism of that damage have remained uncertain. We now present evidence that incorporation of misread proteins into the membrane can account for...
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Antimicrobials are classified according to their chemical structure. Each class is characterized by a typical core structure and various members of the class are differentiated by the addition or removal of secondary chemical structures (1, 2). Antimicrobials can also be classified as broad or narrow spectrum, depending on the range of bacterial species against which they are active, or as bact...
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Background & Aims : Aminoglycosides are powerful bactericidal agents used in combination with betalactams or gelicopeptitds, particularly in the treatment of staphylococcal infections. The main objective of this study was to investigate phenotypic and genotypic properties of aminoglycoside resistance in methicillin resistant S. aureus. Materials & Methods : During 8 months, out of 98 Stap...
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عنوان ژورنال:
- Microbiological reviews
دوره 51 3 شماره
صفحات -
تاریخ انتشار 1987